Polymeric nano-hydroxyapatite coated with polylactic acid (PLA): considering new possibilities for radiopharmacy

ABSTRACT

The use of nanotechnology – especially in the area of human health – is increasing every day, with the application of various materials such as hydroxyapatite being amongst the most studied. Consequently, the affinity of hydroxyapatite compatible with so many applications in the human body is evolving cutting edge technology – the result of which is nanoparticles. However, despite these important developments in nanotechnology, encapsulating a nano-hydroxyapatite is still at an early stage of development warranting further investigation.

In this article, we describe a successful method which uses polylactic acid as the polymer to encapsulate nano-hydroxyapatite: this culminates in new applications for oncology and radiopharmacy. In essence, it is the ability to link a radionuclide and /or other substances, e.g. aptamers to enable the creation of new nanoparticle(s) thereby providing novel structural features which are adjuvant to its conventional use.

Key words: radiopharmaceuticals; nanotechnology; oncology; atomic force microscopy; nano-hydroxyapatite

Citation: de Souza Albernaz M, Gilberto Weissmuller G, Linhares Rossi A, Malta Rossi A, Santos-Oliveira R. Polymeric nano-hydroxyapatite coated with polylactic acid (PLA): considering new possibilities for radiopharmacy. Journal of Diagnostic Imaging in Therapy. 2015; 2(1): 9-17.

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DOI: http://dx.doi.org/10.17229/jdit.2015-0210-012

Copyright: © 2015 Santos-Oliveira R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cited.


Received: 27 January 2015 | Revised: 09 February 2015 | Accepted: 10 February 2015

Published Online 10 February 2015 http://www.openmedscience.com

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JDIT-2015-0210-012